Stereochemical revision of xylogranatin F by GIAO and DU8+ NMR calculations
نویسندگان
چکیده
منابع مشابه
Toward the stereochemical assignment and synthesis of hemicalide: DP4f GIAO-NMR analysis and synthesis of a reassigned C16-C28 subunit.
Using the DP4f GIAO-NMR method, the stereochemistry of hemicalide was computationally analysed, resulting in a reassignment at C18 as supported by improved NMR shift correlations with a model C13-C25 fragment 23. An advanced C16-C28 subunit 6 of this potent anticancer agent was then synthesised with the revised 18,19-syn relationship.
متن کاملEnantioselective total synthesis of batzelladine F: structural revision and stereochemical definition.
In 1997, Patil and co-workers reported the isolation of batzelladines F-I from a red Jamaican sponge incorrectly identified at the time as Batzella sp.1,2 These alkaloids each contain two tricyclic guanidines and were found to induce dissociation of protein tyrosine kinase p56lck from CD4. It was postulated that disruption of this interaction could be used to treat autoimmune disorders. Our int...
متن کاملTotal synthesis and stereochemical revision of xiamenmycin A.
The relative and absolute configurations of xiamenmycin A, a benzopyran compound isolated from Streptomyces xiamenensis 318 with a highly potent anti-fibrotic activity, have been characterized through the total synthesis. The key steps include the construction of the 3-chromanol moiety via Sharpless epoxidation followed by regio- and diastereo-selective cyclization and introduction of the threo...
متن کاملConcise total synthesis and stereochemical revision of all (-)-trigonoliimines.
The concise and enantioselective total syntheses of (-)-trigonoliimines A, B, and C are described. Our unified strategy to all three natural products is based on asymmetric oxidation and reorganization of a single bistryptamine, a sequence of transformations with possible biogenetic relevance. We revise the absolute stereochemistry of (-)-trigonoliimines A, B, and C.
متن کاملTotal synthesis and stereochemical revision of lagunamide A.
A revised configurational assignment for the marine metabolite lagunamide A is proposed and validated by total synthesis.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Chirality
سال: 2020
ISSN: 0899-0042,1520-636X
DOI: 10.1002/chir.23189